Table 4.
Top 40 significantly (by FDR) differentially expressed genes of characterized proteins between high- and low-MWT steers from Angus, Charolais, and Kinsella Composite populations
| Angus | Charolais | Kinsella Composite | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | logFC1 | FDR2 | Gene | logFC1 | FDR2 | Gene | logFC1 | FDR2 |
| GPX3 | −2.55 | 5.66E-37 | SERPINA3 | 4.94 | 1.74E-99 | TMEM45A | −5.23 | 2.12E-119 |
| IFI27 | 2.50 | 1.14E-35 | CYP2B6 | −1.57 | 2.13E-17 | HOPX | −1.76 | 1.53E-17 |
| SERPINA3 | −2.45 | 9.25E-32 | BOLA-DQB | −1.83 | 1.04E-13 | SERPINA3 | −1.73 | 1.04E-16 |
| IFI6 | 1.98 | 5.95E-22 | IGLC1 | −1.44 | 5.06E-13 | IFI27 | 1.64 | 3.16E-15 |
| SERPINA3 | −2.51 | 4.61E-21 | TMEM45A | −1.25 | 2.49E-11 | IFI6 | 1.54 | 5.51E-14 |
| GPNMB | −1.57 | 1.91E-14 | ECEL1 | 1.17 | 6.28E-10 | GPX3 | −1.36 | 3.81E-11 |
| SERPINI2 | 1.73 | 5.62E-13 | AC108941.2 | 1.16 | 6.19E-08 | CYP2B6 | −1.36 | 1.02E-10 |
| HBB | 1.99 | 5.62E-13 | KEL | 1.20 | 6.19E-08 | FBLN2 | −1.36 | 6.92E-09 |
| AKR1B15 | −1.58 | 1.39E-12 | FBLN2 | 1.17 | 6.19E-08 | WFS1 | −1.21 | 1.34E-08 |
| AC108941.2 | 1.37 | 1.84E-11 | HOPX | −1.02 | 2.74E-07 | CTGF | 1.53 | 5.43E-08 |
| SDS | 1.37 | 5.82E-11 | FGF21 | −1.12 | 7.30E-07 | HBB | 1.32 | 1.72E-07 |
| AIF1L | −1.27 | 6.18E-10 | S100A10 | 0.97 | 2.04E-06 | CXCL9 | 1.29 | 5.13E-07 |
| TMEM45A | 1.26 | 9.39E-09 | PLA2G2D | 1.41 | 2.12E-06 | UGT2B7 | −1.08 | 7.53E-07 |
| SULT2A1 | −1.16 | 5.72E-08 | PLTP | 0.92 | 7.78E-06 | CYP3A7-CYP3A51P | −1.19 | 7.53E-07 |
| CKAP4 | −1.10 | 2.23E-07 | IL1B | 1.11 | 8.46E-06 | ATP5MGL | −1.47 | 9.00E-07 |
| RAP1GAP | −1.22 | 1.55E-06 | KCTD12 | 1.02 | 1.93E-05 | PIM1 | −1.06 | 1.74E-06 |
| NUF2 | 1.44 | 1.55E-06 | CSF2RB | 0.93 | 4.06E-05 | IGHG1 | 1.06 | 2.99E-06 |
| TNC | 1.08 | 1.55E-06 | SFRP1 | −0.87 | 4.19E-05 | ZNF385B | −1.21 | 4.85E-06 |
| CDHR5 | −1.00 | 5.21E-06 | MARCO | 0.85 | 6.56E-05 | IGLC1 | 1.39 | 9.42E-06 |
| SLC13A2 | −1.11 | 6.80E-06 | PRAP1 | −1.00 | 8.72E-05 | IGLC1 | 1.00 | 2.61E-05 |
| ROS1 | 1.32 | 9.40E-06 | FAM47E | −1.01 | 1.05E-04 | BoLA-DQB1 | 0.97 | 3.59E-05 |
| HP | −1.57 | 1.81E-05 | HLA-DQB1 | 1.05 | 1.25E-04 | CES1 | 0.94 | 4.26E-05 |
| AK4 | 0.92 | 6.05E-05 | CSF1R | 0.83 | 1.84E-04 | SERPINI2 | 1.08 | 4.26E-05 |
| DENND2A | −0.89 | 1.12E-04 | UCP2 | 0.80 | 3.12E-04 | ASIP | 1.00 | 9.88E-05 |
| SFRP2 | 0.89 | 1.16E-04 | ADGRE1 | 0.79 | 3.31E-04 | UGT2B7 | 0.91 | 1.57E-04 |
| SDCBP2 | 1.20 | 2.19E-04 | PTN | 0.91 | 3.31E-04 | ACE2 | 0.88 | 1.79E-04 |
| CYP2B6 | 0.88 | 4.01E-04 | IGHA1 | −0.89 | 5.98E-04 | HP | −1.34 | 1.89E-04 |
| PLCD4 | −0.89 | 4.20E-04 | SLC13A2 | 1.02 | 1.05E-03 | AKR1C1 | 1.01 | 2.44E-04 |
| FAM13A | 0.99 | 4.81E-04 | PDK4 | 0.79 | 1.15E-03 | REEP5 | −0.86 | 3.59E-04 |
| GNMT | 0.82 | 6.79E-04 | PTGS1 | 0.75 | 1.23E-03 | TGM2 | 0.85 | 4.61E-04 |
| CFH | 0.95 | 7.04E-04 | FADS1 | 0.91 | 1.25E-03 | CDH11 | −0.99 | 5.44E-04 |
| CYR61 | 0.94 | 1.04E-03 | SLC7A5 | 1.00 | 1.46E-03 | PRAP1 | 0.85 | 5.49E-04 |
| ABHD6 | 0.85 | 1.44E-03 | SOAT2 | 0.86 | 1.94E-03 | DDO | 0.99 | 6.82E-04 |
| HMGCR | −0.83 | 1.44E-03 | PPP1R3C | −0.74 | 2.00E-03 | CARNS1 | 0.88 | 1.00E-03 |
| GPC3 | 0.81 | 1.76E-03 | IGHG1 | −0.71 | 2.79E-03 | SLCO4A1 | −0.95 | 1.46E-03 |
| BICC1 | −0.96 | 2.27E-03 | LPIN1 | 0.72 | 2.96E-03 | RAB20 | −0.81 | 1.62E-03 |
| IGFBP2 | −0.80 | 2.49E-03 | IGLV2-18 | −0.95 | 2.96E-03 | RFLNA | −0.83 | 1.74E-03 |
| ISG15 | 0.76 | 3.08E-03 | RASL10A | 0.99 | 3.33E-03 | SDS | −0.81 | 1.91E-03 |
| PRAP1 | 0.79 | 3.30E-03 | TMEM176B | 0.71 | 4.09E-03 | ECEL1 | 0.88 | 2.09E-03 |
| DLK1 | 0.97 | 3.49E-03 | SMPDL3B | 0.81 | 4.75E-03 | CLDN15 | 0.78 | 2.09E-03 |
1log2FC = log2(fold change of a gene in low metabolic body weight [MWT] animals with reference to high-MWT animals).
2FDR = false discovery rate adjusted P-value.