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. 2019 Sep 21;97(11):4428–4444. doi: 10.1093/jas/skz299

Figure 7.

Figure 7.

Immune response mechanisms associated with natural H. contortus infection. . Significant polymorphisms in ITGA4 and MUC15 genes are related to initial rejection of the larvae. For innate immune response, significant SNPs were identified in TLR3 and PCDH7 genes. For the inflammatory response, significant polymorphisms in CXCL10 and TNF genes were observed. Activation of mature eosinophils, antigen recognition by T cells, T-cell proliferation, Th17 signaling, protection against oxidative damage, Treg signaling, and Th2 response were related to significant SNPs within CCL26, IL16, STAT3, GPX2, IL2RB, and STAT6 genes, respectively.