Table 4.
Immunological pathways related to H. contortus FEC, FAMACHA score, red blood cell count (RBC), hemoglobin level (HGB), white blood cell count (WBC), neutrophil count (NEU), basophil count (BC), and eosinophil count (EC) in Florida Native sheep; Gene = gene name; GO term = gene ontology pathway name; Number of genes in gene list = number of genes from list identified in the pathway; Number of genes in GO term = total number of genes included in the GO term
| Trait | Gene | GO term | GO term name | Number of genes in gene list | Number of genes in GO term |
|---|---|---|---|---|---|
| FEC | ITGA4, STAT3, MUC15, IL2RB, CFI | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 2 | 6 |
| GO:0043373 | CD4-positive, alpha-beta T-cell lineage commitment | 2 | 8 | ||
| GO:0002295 | T-helper cell lineage commitment | 2 | 8 | ||
| GO:0070102 | Interleukin-6-mediated signaling pathway | 2 | 9 | ||
| GO:0072540 | T-helper 17 cell lineage commitment | 2 | 6 | ||
| GO:0072539 | T-helper 17 cell differentiation | 2 | 6 | ||
| GO:0072538 | T-helper 17 type immune response | 2 | 6 | ||
| GO:1905562 | Regulation of vascular endothelial cell proliferation | 2 | 11 | ||
| GO:1905564 | Positive regulation of vascular endothelial cell proliferation | 2 | 7 | ||
| GO:0060259 | Regulation of feeding behavior | 2 | |||
| GO:0033210 | Leptin-mediated signaling pathway | 2 | 9 | ||
| GO:0044320 | Cellular response to leptin stimulus | 2 | 12 | ||
| FAMACHA score | IL2RB, GPX2 | GO:0098869 | Cellular oxidant detoxification | 1 | 86 |
| GO:0019221 | Cytokine-mediated signaling pathway | 1 | 91 | ||
| RBC, HGB | IL16 | GO:0005125 | Cytokine activity | 1 | 173 |
| WBC | STAT6, PCDH7, MUC15 | GO:0042093 | T-helper cell differentiation | 1 | 17 |
| GO:0002295 | T-helper cell lineage commitment | 1 | 8 | ||
| GO:0002294 | CD4-positive, alpha-beta T-cell differentiation involved in immune response | 1 | 17 | ||
| GO:0035771 | Interleukin-4-mediated signaling pathway | 1 | 2 | ||
| GO:0048295 | Positive regulation of isotype switching to IgE isotypes | 1 | 2 | ||
| NEU | CXCL10, TNF | GO:0002439 | Chronic inflammatory response to antigenic stimulus | 1 | 1 |
| GO:1901740 | Negative regulation of myoblast fusion | 1 | 1 | ||
| BC | CCL26 | GO:0031728 | CCR3 chemokine receptor binding | 1 | 4 |
| EC | ITGA4, TLR3 | GO:0034138 | Toll-like receptor 3 signaling pathway | 2 | 4 |