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CDR-L1 and CDR-L2 Sequences of Designed Ranibizumab Variants
| Fab |
CDR-L1 |
CDR-L2 |
pI |
Fv HI |
| Ranibizumab WT | SASQDISNYLN | FTSSLHS | 8.1 | 1212 |
| RBZ–3 | SASQDISNYLN | DTSDLES | 6.8 | 1163 |
| RBZ+7 | RARQGIRNYLN | KTSRRHS | 10.2 | 1009 |
| RBZ-HI low | QASQDISNSLN | STSNLHS | 8.9 | 1165 |
| RBZ-HI high | SVSQVISSWLA | FASSLQT | 9.1 | 1296 |
