The network is remarkable for extensive interactions with progranulin (GRN, center of network), genes implicated in immunological function (CD81, HLA-A, HLA-B and HLA-E), lysosomal genes (CTSB, CTSD, GAA, LAPTM5, LRP1, NPC2 and TPP1), genes implicated in neurodegenerative lysosomal storage disorders (CTSD, GRN, NPC2 and TPP1), and a gene implicated in familial dementia (ITM2B). The network diagram was generated using HumanBase, a publicly available online database and analytical pipeline hosted by the Flatiron Institute (http://www.simonsfoundation.org/flatiron/). We limited our search to high-quality, brain-specific relationships connected to the query genes through co-expression, protein interaction, or shared transcription factor binding. Query genes are located on the periphery of the network to facilitate visualization of their connections with interacting network genes. The thickness of a connection represents edge weight, or strength of ties. Connection color represents ‘evidence’ for an edge, defined as the posterior probability of a functional relationship given the brain-tissue specific connectivity dataset, minus the prior probability. Detailed descriptions of the techniques used are provided in Greene et al., 2015 [56] and at https://humanbase.readthedocs.io/en/latest/functional-networks.html.