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. 2019 Oct 25;7(1):e000783. doi: 10.1136/bmjdrc-2019-000783

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Empagliflozin (Empa) increased uncoupling protein 1 (Ucp1) expression in both brown (BAT) and white (WAT) adipose tissues. (A) BAT sections stained using H&E. Scale bars=100 µm. (B) Immunoblots of Ucp1 in BAT. (C) Levels of thermogenesis-related gene mRNAs in the BAT. (D) Immunoblots of Ucp1 in the inguinal (iWAT) and epididymal (eWAT) WAT. (E) Levels of browning-related gene mRNAs in the iWAT. Data are presented as means±SEM, n=7–8. *P<0.05 and **p<0.01, respectively, for comparisons with normal chow (NC)-fed mice; #p<0.05 and ##p<0.01, respectively, for comparisons with high-fat diet (HFD)-fed mice.