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. 2019 Oct 17;7(1):e000650. doi: 10.1136/bmjdrc-2019-000650

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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IL-1α deficiency reduced eWAT weight and adipocyte size without affecting total body weight. (A) Body weight, (B) eWAT weight, (C) eWAT histology with H&E and (D) adipocyte size quantification in male Loxp and IL-1α KO mice (6 weeks of age at start of dietary intervention) fed either regular chow or HFD (n=7–12 per group) for 16 weeks. Data are presented as mean±SE. Asterisk/dollar/Hash marks depict statistically significant differences. **p≤0.01 ***p≤0.001 to Loxp. ###p≤0.001 to chow (two-way ANOVA). $$$p≤0.001 between chow to HFD (three-way mixed design ANOVA). ANOVA, analysis of variance; H&E, hematoxylin and eosin; HFD, high-fat diet; IL, interleukin; KO, knockout.