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. 2019 Oct 17;7(1):e000650. doi: 10.1136/bmjdrc-2019-000650

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Fasting plasma cholesterol and TG levels were lower in IL-1α KO compared with Loxp mice. Fasting total plasma cholesterol (A, upper panel) and TG (B, upper panel) levels in male Loxp and IL-1α KO mice fed either regular chow or HFD (n=7–12 per group) for 8 weeks. Analysis of the distribution of plasma lipoprotein cholesterol (A, lower panel) and TG (B, lower panel) was performed with FPLC. Blood was obtained from fasted animals and plasma samples were pooled in each group. Data are presented as mean±SE. Asterisks/Hash marks depict statistically significant differences. ***p≤0.001 to Loxp. ###p≤0.001 to chow (two-way ANOVA). ANOVA, analysis of variance; FPLC, fast protein liquid chromatography; HFD, high-fat diet; IL, interleukin; KO, knockout; TG, triglyceride.