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. 2019 Oct 17;7(1):e000650. doi: 10.1136/bmjdrc-2019-000650

Figure 6.

Figure 6

IL-1α deficiency lowered the expression of genes that promote hepatic DNL. (A) The mRNA expression levels of SCD1, FASN, ELOVL6, ACCα, DGAT, ChREBP, Srebpf-1c and LXR in livers of Loxp (control) and IL-1α KO mice-fed HFD for 16 weeks. (B) mRNA expression levels of ELOVL6 and FASN in primary mouse hepatocytes treated either with DMSO (control) or recombinant IL-1α for 24 hours. Data are presented as mean±SE. Asterisks depict statistically significant differences. *p≤0.05; **p≤0.01 to control mice/cells (student’s t-test). ACCα, acetyl-CoA carboxylase α; ChREBP, carbohydrate response element binding protein; DGAT, diacylglycerol acyltransferase; DMSO, dimethyl sulfoxide; DNL, de-novo lipogenesis; ELOVL6, elongation of long-chain fatty acids family member 6; FASN, fatty acid synthase; IL, interleukin; KO, knockout; LXR, liver X receptor; SCD1, stearoyl-CoA desaturase1; Srebpf-1c, sterol regulatory element-binding protein 1.