Fig. 3.

DNA repair defects can improve OS in GBM. Differentially expressed genes upregulated in LTS or STS were uploaded into IPA and core analysis of expression was performed for (A) IDH-wildtype GBMs with TERT promoter mutations and (B) all IDH-wildtype GBMs. (C, D) One LTS and derivative PDX (GBM84) demonstrated an ATRIP deficiency and profound DNA repair signaling defects following TMZ dosing compared with another MGMT methylated PDX (GBM12). (E) Analysis of REMBRANDT expression data showed that decreased ATRIP expression correlated with better survival in GBM patients.