Table 2. First passage of PMCA and PMSA-adapted recombinant samples inoculated into bank voles.

Inoculum	Substrate	Model	Survival time of positive animals (dpi) (mean±SEM)	Attack ratea
CWDb	Brain	Bank vole	37±1	9/9 (100%)
L-seeded-PMCAc	PMCA	Bank vole	239±46	8/8 (100%)
L-seeded-PMSA (1)	PMSA	Bank vole	318±3	4/4d (100%)

^a Data obtained based on clinical signs and protease-resistant PrP detection.

^b Data obtained and published previously using CWD: Chronic Wasting Disease adapted to bank vole I109 (10).

^c Data obtained and published previously using the dextran-complemented recombinant sample (10).

^d From a group of eight animals, four had to be killed due to unrelated intercurrent disease and were excluded from these calculations.

SEM: Standard Error of Mean. dpi: day post inoculation.