Table 3. Titration of the PMSA-adapted recombinant samples inoculated into TgVole (1x).
Inoculum | Dilution | Model | Survival time of positive animals (dpi) (mean±SEM) |
Attack ratea |
---|---|---|---|---|
L-seeded-PMSA (1) | 10−1 | TgVole | 266±3 | 10/10 (100%) |
L-seeded-PMSA (1) | 10−2 | TgVole | 281±6 | 4/4 (100%) |
L-seeded-PMSA (1) | 10−4 | TgVole | 321±6 | 5/5 (100%) |
L-seeded-PMSA (1) | 10−5 | TgVole | 434±21 | 2/5 (40%) |
a Data obtained based on neurological clinical signs and protease-resistant PrP detection.
SEM: Standard Error of Mean. dpi: day post inoculation.