Table 2. SLFN11 mRNA expression is commonly associated with chemosensitivity in cancer cell lines.

All genes listed here were correlated with sensitivity (R≤-0.2) or resistance (R≥0.2) in >50% of drugs in class in ≥2 databases (CTRP, GDSC, or NCI60). Bold indicates overlap in all 3 databases. Underline indicates overlap with topoisomerase-sensitizing genes reported in ref. [16].

Drug class	Genes associated with sensitivity	Genes associated with resistance
Alkylating agents	PFAS, SLFN11	LSR, MST1R, OSBPL2, PLEKHA7
Anti-metabolites	CSNK2A2, EP400, EXOSC2, LIMD2, METAP2, MRPS27, NOB1, NPM3, PFAS, PPP1CC, SLFN11, TRAP1, ZNF280C	PTTG1IP
Anti-tumor Antibiotics	ATF1, BLMH, METAP2, MEX3B, MIR600HG, NSL1, RGS16, RTN1, SLFN11, TATDN3, ZFP1	C3orf52, EIF6, TPD52L2, TPRG1L
Microtubule Inhibitors	AGPAT5, ALMS1, ANP32B, ATXN7L2, C15orf61, C2orf44, CECR5, CEP85, CNTRL, COQ3, CRLF3, DKC1, EXOSC2, FBXO45, GMEB1, GNL2, HMGXB4, HNRNPR, IKBKAP, ITGB3BP, KBTBD6, KDM1A, KIF2A, MAK16, NASP, NCBP1, NUP160, NUP188, NUP88, ODF2, OIP5, ORC1, OTUD3, POLA1, POLR1E, PWP2, RCC2, RMI1, RPA2, RUVBL1, SKP2, SNRPA, SPAST, SPATA5L1, TAF5, TBPL1, TTF1, TTI2, TUBGCP4, TXLNG, UPF3B, WDR18, WRAP73, ZNF142, ZNF184, ZNF227, ZNF280C	ABCB1, ALDH3B1, BCL2L1, BICC1, CFLAR, COMMD7, DRAM1, DYSF, EHD1, GALNT10, GLS, GRAMD3, ITGA3, LASP1, LEPROT, MGLL, MVP, NPC2, PHLDA3, PLK2, SLC35F5, SUMF1, TGM2, THBS1, TNFRSF12A, TRAM1, UGCG, UXS1, ZFP36L1
Topoisomerase Inhibitors	ANGEL2, ANP32B, ANTXR1, ATG4C, BCAT1, BLMH, BPTF, CAPRIN1, CASC3, CSNK1E, DLG4, DNAJC7, DSE, EP400, FAM129A, HAND2, HMX2, KHDRBS1, KIF5C, MEX3B, MRC2, MRPL42, NAP1L1, NSL1, NUCKS1, NUDT10, PHF21A, PPM1E, PSIP1, RAB39B, RTN1, SENP1, SLFN11, SNHG1, SNRPF, TCF4, TGFB1, TLK2, VBP1, WASF1, ZFHX4, ZFP1, ZNF280C, ZNF483	CLDN4, LIPH, SLC35A2, CEACAM5, CHKA, ELF3, EPCAM, LSR, MANSC1, MISP, OVOL2, PPFIBP2, PRR15, RAB11FIP4, RAB17, RASEF, RDH13, SHROOM3, ARHGEF5, B4GALT4, FUCA1, GIPC1, OSBPL2, TMEM184B, TNFRSF21, TPRG1L