Table 1.
Genetic mutation in components of Wnt/β-catenin pathway in HCC
| References | Patients | Mutant samples | Region | |||
|---|---|---|---|---|---|---|
| CTNNB1 | AXIN1 | AXIN2 | APC | |||
| Rebouissou et al. [39] | 373 | 146 (39%) | NA | NA | NA | France, Spain, Italy |
| Hirotsu et al. [40] | 9 | 2 (22.2%) | NA | NA | NA | Japan |
| Schulze et al. [41] | 243 | 95 (37.4%) | 27 (11.1%) | 3 (1.2%) | 4 (1.6%) | France, Italy, Spain |
| Kan et al. [42] | 88 | 14 (15.9%) | 4 (4.5%) | 2 (2.3%) | 2 (2.3%) | China |
| Kitao et al. [43] | 134 | 27 (20.1%) | NA | NA | NA | Japan |
| Ding et al. [44] | 156 | 15 (9.6%) | NA | NA | NA | China |
| Tornesello et al. [45] | 67 | 10 (14.9%) | NA | NA | NA | Southern Italy |
| Cleary et al. [46] | 87 | 20 (22.9%) | NA | NA | NA | Canada, NC |
| Guichard et al. [47] | 125 | 41 (32.8%) | 19 (15.2%) | NA | 2 (1.6%) | France |
| Lachenmayer et al. [48] | 90 | 29 (32.2%) | NA | NA | NA | USA, Netherlands, Italy, Spain, Germany |
| Li et al. [49] | 139 | 28 (20.1%) | NA | NA | NA | USA, Netherlands, China |
| Cieply et al. [50] | 32 | 9 (28.1%) | NA | NA | NA | USA |
| Bengochea et al. [38] | 62 | 16 (25.8%) | NA | NA | NA | Thailand, France |
| Austinat et al. [51] | 40 | 10 (25%) | 2 (5%) | NA | NA | Germany |
| Kim et al. [52] | 36 | 1 (2.8%) | 9 (25%) | NA | NA | Korea |
| Zucman-Rossi et al. [53] | 45 | 18 (40%) | 5 (11.1%) | NA | NA | France |
| Boyault et al. [54] | 120 | 34 (28.3%) | 13 (10.8%) | NA | NA | France |
| Zucman-Rossi et al. [55] | 96 | 12 (12.5%) | NA | NA | NA | France |
| Park et al. [56] | 81 | 13 (16%) | 5 (6.2%) | NA | NA | Korea |
| Ishizaki et al. [57] | 89 | 10 (11.2%) | 13 (14.6%) | 9 (10.1%) | NA | Japan |
| Cui et al. [58] | 34 | 15 (44.1%) | NA | NA | NA | China |
| Edamoto et al. [59] | 100 | 24 (24%) | NA | NA | 0 | Japan, Switzerland |
| Taniguchi et al. [60] | 73 | 14 (19.2%) | 7 (9.6%) | 2 (2.7%) | NA | UK |
| Wong et al. [61] | 60 | 7 (11.7%) | NA | NA | NA | China |
| Mao et al. [62] | 262 | 37 (14.1%) | NA | NA | NA | Taiwan |
| Cui et al. [63] | 34 | 15 (44.1%) | NA | NA | NA | China |
| Laurent-Puig et al. [64] | 137 | 26 (19%) | 12 (8.8%) | NA | NA | France |
| Devereux et al. [65] | 62 | 5 (8.1%) | NA | NA | NA | China |
| Hsu et al. [66] | 434 | 57 (13.1%) | NA | NA | NA | Taiwan |
| Satoh et al. [67] | 87 | 0 (0%) | 5 (5.7%) | NA | NA | Japan |
| Huang et al. [68] | 22 | 9 (41%) | NA | NA | NA | Japan, Switzerland |
| Legoix et al. [69] | 119 | 21 (17.6%) | NA | NA | NA | France |
| Terris et al. [70] | 73 | 14 (19.2%) | NA | NA | NA | France |
| Kondo et al. [71] | 38 | 9 (24%) | NA | NA | NA | Japan |
| Nhieu et al. [72] | 35 | 12 (34.3%) | NA | NA | NA | France |
| Miyoshi et al. [73] | 75 | 14 (18.7%) | NA | NA | NA | Japan |
| de La Coste et al. [74] | 31 | 8 (25.8%) | NA | NA | NA | France |
| Total | 3788 | 837 (22.1%) | 121 (10.4%) | 16 (3.3%) | 8 (1.4%) | |
NA not analyzed