Fig. 3.

Global gene expression analysis in engineered DCIS.COM cells.a Summary of gene expression changes found by microarray analysis of the DCIS.COM cell lines after a 24-h hormone treatment. The Illumina HumanHT-12 v4.0 Gene Expression Beachchip Assay was used. Genes were selected based on the criteria of a fold-change greater than 1.25 with a p value of less than 0.05. The patterned areas indicate commonly regulated genes, with the solid color showing genes uniquely expressed in that cell line. b Dendrogram integrating our gene expression profiling of ER+/PR+ DCIS.COM cells with a public specimen cohort of patient DCIS and tumor samples (normal-like, basal, HER2-enriched, and luminal subtypes)