Table 1.
Number of patients | 492 |
Median age (years, range) | 53 (26–76) |
Menopausal status | |
Postmenopausal | 58% |
Premenopausal | 42% |
Adjuvant therapy | |
FAC/FEC/AC/EC × 6 cycles | 148 |
FAC/FEC/AC/EC × 4 cycles → weekly paclitaxel × 8–12 cycles | 29 |
Epirubicin 90 mg/m2 plus docetaxel 75 mg/m2 × 4 cycles → Capecitabine × 4 cycles | 31 |
TAC × 6 cycles | 74 |
A/E+/−C × 4 cy → docetaxel 100 mg/m2 × 4 cycles +/−trastuzumab | 66 |
Tamoxifena | 57 |
Aromatase inhibitorsb | 87 |
Characteristic of the patients and therapy (HCSC)
HCSC, Hospital Clinico San Carlos, Madrid; FAC: 5-fluorouracil, doxorubicin, cyclophosphamide; FEC, 5-fluorouracil, doxorubicin, cyclophosphamide; AC/EC, doxorubicin or epirubicin plus cyclophosphamide; TC, docetaxel 75 mg/m2 plus cyclophsphamide; TAC, docetaxel 75 mg/m2, doxorubicin, cyclophosphamide; TCH, docetaxel 75 mg/m2, carboplatin AUC 6, trastuzumab
aWithout prior adjuvant chemotherapy
bWithout prior adjuvant chemotherapy; some patients included in this group have received tamoxifen followed by an aromatase inhibitor