Table 5:

Univariate and multivariable analyses for pericardial effusion (any grade) for patients treated with NA CRT followed by surgery.

Variable	Univariate Analysis			Multivariable Analysis
	HR	95% CI	p-value	HR	95% CI	p-value
Age at Diagnosis	0.97	0.9 – 1.04	0.33
Sex (Male)	2.24	0.49 – 10.13	0.30
ECOG Score	0.69	0.28 – 1.68	0.41
BMI	1.05	0.96 – 1.14	0.32
Diabetes (No)	0.86	0.29 – 2.55	0.79
HTN (No)	1.99	0.87 – 4.6	0.11
Smoking (Never)	2.04	0.88 – 4.71	0.09
Pre-Existing Cardiac Disease (Yes)	1.16	0.40 – 3.53	0.83
Clinical Stage (I)	1.05	0.39 – 2.85	0.92
Location (GE Junction)	1.2	0.49 – 2.91	0.69
Radiation Modality (IMRT)	0.42	0.14 – 1.26	0.12
Gross Tumor Volume	1.01	1 – 1.01	0.01	1.01	1 – 1.01	0.016
Heart Mean Dose	1.06	0.99 – 1.14	0.10
Heart Max	0.98	0.9 – 1.07	0.70
V5	1.01	0.97 – 1.04	0.73
V10	1.01	0.98 – 1.04	0.74
V15	1	1 – 1	0.06
V20	1.01	0.99 – 1.04	0.31
V25	1.02	0.99 – 1.04	0.17
V30	1.02	1 – 1.04	0.08
V35	1.02	1 – 1.04	0.03
V40	1	1 – 1	0.09
V45	1.03	1.01 – 1.05	0.001	1.03	1.01 – 1.06	0.012
V50	1.04	1 – 1.08	0.04

Abbreviations: BMI, body mass index; HTN, hypertension; GE, gastro-esophageal; IMRT, intensity-modulated radiation therapy; NA CRT, neoadjuvant chemoradiotherapy