Figure 10.

In vivo 2OMG CEST MRI measurements in a 4T1 tumor (7T field). (A) A T₂-RARE anatomical image before administration of the agent; (B) MTR_asym image at 1.0 ppm following treatment with 2OMG (3 g/kg, IP), overlaid onto the T₂ anatomical image; (C) The MTR_asym plots for 4T₁ tumor before (red curve) and after treatment (green curve) with 2OMG. In the inset: full Z spectra for 4T₁ tumor at two-time periods following administration of 2OMG; total estimated time of scan was 80 min (same CEST protocol as described in Figure 8 caption). Rivlin M, 2018, unpublished results.