Figure 7.

3-O-Methyl-D-glucose (3OMG) chemical exchange saturation transfer (CEST) MRI and ¹⁸FDG PET/CT images from five tumors of a murine model (4T1 cells). (A) A coronal view of an anatomical T₂-weighted MR images (7T field) before 3OMG administration showing the tumor (green arrow) and the urinary bladder (red arrow). (B) % CEST images 60 min after PO administration with 3OMG, 1.0 g/kg (at a frequency offset of 1.2 ppm, B₁=2.4 µT). A significant CEST contrast was obtained in the tumor and the urinary bladder as well as areas suspected to be metastases. (C) ¹⁸FDG PET/CT coronal view obtained 60 min after IV injection of ¹⁸FDG showing accumulation mainly in the tumor (green arrow) and urinary bladder (red arrow). (D) Correlation between 3OMG % CEST contrast and % ID/mL value in the five tumors from a murine model ± SD. The CEST and PET/CT measurements were performed 8 and 10 days after implantation of the tumors, respectively (29).