Summary of findings 5. Community health educational interventions compared to control in LMICs: Sensitivity analysis on primary outcomes.
| Community health educational interventions compared to control in developing countries in LMICs: sensitivity analysis | ||||
| Patient or population: developing countries Setting: low‐middle‐income countries, community Intervention: community health educational interventions Comparison: control | ||||
| Outcomes | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments |
| Neonatal mortality | RR 0.88 (0.79 to 0.98) | 497,258 (22 RCTs) | ⊕⊕⊝⊝ Moderatea | Not all confidence intervals from these studies overlap; there is also inconsistency in direction across studies |
| Early neonatal mortality | RR 0.71 (0.62 to 0.82) | 26,472 (11 RCTs) | ⊕⊝⊝⊝ Moderatea | Most studies overlap and are in the same direction of effect; however there is one major outlier that is also in the opposite direction. The statistical measure for heterogeneity is also high, suggesting inconsistency |
| Late neonatal mortality | RR 0.51 (0.36 to 0.72) | 150,867 (9 RCTs) | ⊕⊝⊝⊝ Moderatea | I² (88%) was considerably large; however most confidence intervals overlap, and there is consistent direction of effect |
| Perinatal mortality | RR 0.84 (0.75 to 0.94) | 262,613 (12 RCTs) | ⊕⊝⊝⊝ Moderatea | I² (81%) is considerably large; some studies (although with small weighting) support the control, and others support the intervention. Most confidence intervals overlap; however some CIs are large |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RCT: randomised controlled trial; RR: risk ratio. | ||||
| GRADE Working Group grades of evidence. High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||
aInconsistency.