Table 2.
Top 10 differentially expressed miRNAs in each group (Poisson distribution screening)
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Comparison of top 10 differentially expressed miRNAs |
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VCAM-1 group vs control group |
TNFα group vs control group |
IL6 group vs control group |
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| miRNA id | Count (control) | Count (VCAM-1) | TPM (control) | TPM (VCAM-1) | Log2 ratio (VCAM-1/control) | Up/down-regulation (VCAM-1/control) | P | FDR | miRNA id | Count (control) | Count (TNFα) | TPM (control) | TPM (TNFα) | Log2 ratio (TNFα/control) | Up/down-regulation (TNFα/control) | P | FDR | miRNA id | Count (control) | Count (IL6) | TPM (control) | TPM (IL6) | Log2 ratio (IL6/control) | Up/down-Regulation (IL6/control) | P value | FDR | |
| miR-146a-5p | 20510 | 5173 | 1252.18 | 223.98 | -2.483 | Down | 0 | 0 | miR-146a-5p | 20510 | 128078 | 1252.18 | 6175.54 | 2.302123 | Up | 0 | 0 | miR-3529-3p | 473 | 8930 | 28.88 | 278.05 | 3.267202 | Up | 0 | 0 | |
| miR-149-5p | 4558 | 2391 | 278.27 | 103.53 | -1.42644 | Down | 0 | 0 | miR-342-3p | 2117 | 7130 | 129.25 | 343.79 | 1.411363 | Up | 0 | 0 | miR-320c | 1276 | 7983 | 77.9 | 248.57 | 1.673957 | Up | 0 | 0 | |
| miR-222-3p | 89564 | 48444 | 5468.06 | 2097.54 | -1.38233 | Down | 0 | 0 | miR-23a-3p | 42777 | 140623 | 2611.62 | 6780.42 | 1.37643 | Up | 0 | 0 | miR-24-3p | 11151 | 50968 | 680.79 | 1586.99 | 1.221011 | Up | 0 | 0 | |
| miR-29a-3p | 8451 | 5054 | 515.95 | 218.83 | -1.23742 | Down | 0 | 0 | miR-100-5p | 132865 | 408192 | 8111.67 | 19681.79 | 1.278791 | Up | 0 | 0 | miR-7-5p | 16653 | 101 | 1016.7 | 3.14 | -8.33891 | Down | 0 | 0 | |
| miR-451a | 2760 | 77297 | 168.5 | 3346.83 | 4.311975 | Up | 0 | 0 | miR-337-3p | 5655 | 16027 | 345.25 | 772.77 | 1.162398 | Up | 0 | 0 | miR-196a-5p | 26485 | 11440 | 1616.96 | 356.21 | -2.18248 | Down | 0 | 0 | |
| miR-490-5p | 1839 | 475 | 112.27 | 20.57 | -2.44836 | Down | 2.00E-305 | 1.20E-303 | miR-409-3p | 4207 | 11169 | 256.85 | 538.54 | 1.068127 | Up | 0 | 0 | miR-451a | 2760 | 1658 | 168.5 | 51.62 | -1.70675 | Down | 0 | 0 | |
| miR-1246 | 1812 | 6191 | 110.63 | 268.06 | 1.276813 | Up | 1.39E-276 | 8.02E-275 | miR-221-3p | 4067 | 10541 | 248.3 | 508.26 | 1.033482 | Up | 0 | 0 | miR-379-5p | 13430 | 8083 | 819.93 | 251.68 | -1.70391 | Down | 0 | 0 | |
| miR-181a-2-3p | 3400 | 2008 | 207.58 | 86.94 | -1.25558 | Down | 2.31E-219 | 1.18E-217 | miR-7-5p | 16653 | 136 | 1016.7 | 6.56 | -7.27598 | Down | 0 | 0 | miR-196b-5p | 18735 | 15676 | 1143.81 | 488.1 | -1.2286 | Down | 0 | 0 | |
| miR-204-5p | 3116 | 1757 | 190.24 | 76.08 | -1.32223 | Down | 3.36E-218 | 1.66E-216 | miR-196a-5p | 26485 | 8359 | 1616.96 | 403.05 | -2.00425 | Down | 0 | 0 | miR-424-5p | 12774 | 11917 | 779.88 | 371.06 | -1.0716 | Down | 0 | 0 | |
| miR-378e | 2 | 817 | 0.12 | 35.37 | 8.203348 | Up | 4.36E-186 | 2.00E-184 | miR-26b-5p | 6496 | 3410 | 396.59 | 164.42 | -1.27026 | Down | 0 | 0 | miR-26b-5p | 6496 | 6086 | 396.59 | 189.5 | -1.06545 | Down | 0 | 0 | |
P-values were corrected. TPM: Transcripts per kilobase million; FDR: False discovery rate; VCAM-1: Vascular cell adhesion molecule-1; TNF: Tumor necrosis factor; IL6: Interleukin 6.