TABLE 2.

Brain and plasma concentrations following DS2 administration and co-treatment with or without elacridar.

		Plasma (P)		Brain (B)		P ratio	B ratio	B/P ration
		Without ng/ml (μM)	With ng/ml (μM)	Without ng/ml (μM)	With ng/ml (μM)			Without	With
DS2	0.5 h	12,205	12,262	1587	1696	1.0	1.1	0.13	0.14
		(34.5)	(34.7)	(4.5)	(4.8)
	1 h	15,231	13,928	1874	1957	0.9	1.0	0.12	0.13
		(43.2)	(39.5)	(5.3)	(5.5)

Data is expressed as both ng/ml and (μM) concentrations.