Table 1.
In vitro 50% effective concentration (EC50) of free and liposomal sertraline against L. (L.) infantum and mammalian cytotoxicity.
| EC50 (μM) ± SD | ||||
|---|---|---|---|---|
| Drugs | L. (L) infantum promastigotes | L. (L) infantum amastigotes | Cytotoxicity NCTC cells | S.I. |
| SERT | 0.7 ± 0.4 | 4.2 ± 2.2 | 27.4 ± 0.8 | 6.4 |
| LP-SERT | – | 2.5 ± 1.6 | 12.0 ± 2.4 | 4.8 |
| Miltefosine | 16.2 ± 0.02 | 3.1 ± 1.6 | 127.7 ± 6.7 | 40.9 |
EC50, 50% effective concentration; S.I., selectivity index [CC50 mammalian cells/EC50 L. (L) infantum amastigotes]; SERT, free sertraline; LP-SERT, liposomal sertraline; SD, standard deviation; EC50 values are representative of three independent assays.