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. 2019 Oct 29;9:353. doi: 10.3389/fcimb.2019.00353

Table 1.

In vitro 50% effective concentration (EC50) of free and liposomal sertraline against L. (L.) infantum and mammalian cytotoxicity.

EC50 (μM) ± SD
Drugs L. (L) infantum promastigotes L. (L) infantum amastigotes Cytotoxicity NCTC cells S.I.
SERT 0.7 ± 0.4 4.2 ± 2.2 27.4 ± 0.8 6.4
LP-SERT 2.5 ± 1.6 12.0 ± 2.4 4.8
Miltefosine 16.2 ± 0.02 3.1 ± 1.6 127.7 ± 6.7 40.9

EC50, 50% effective concentration; S.I., selectivity index [CC50 mammalian cells/EC50 L. (L) infantum amastigotes]; SERT, free sertraline; LP-SERT, liposomal sertraline; SD, standard deviation; EC50 values are representative of three independent assays.