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. 2019 Oct 29;7:254. doi: 10.3389/fcell.2019.00254

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Copyright © 2019 Nguyen, Chung, Lynch and Ryall.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phospholipid and TAG synthesis via G3P. The glycolytic intermediate G3P, can contribute to phospholipid and TAG synthesis following its initial conversion to DHAP. The nucleoside CTP is required for synthesis of all phospholipids except phosphatidic acid (PA). Key metabolites of this side pathway include PA and diacylglycerol (DAG). Note: not all intermediate steps are shown. CDP-DAG, cytidinediphosphate-diacylglycerol; CL, cardiolipin; LPA, lysophosphatidic acid; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; PI, phosphatidylinositol; PS, phosphatidylserine.