Table 5.
p values, medians, 25th and 75th percentiles, and IQRs for the pairwise comparisons between OA/US features and breast cancer molecular subtypes: LUMA, LUMB, TNBC, and HER2-enriched (HER2-E) breast cancers (N = 59)
| LUMA | LUMB | TNBC | HER2-E | LUMA vs LUMB | LUMA vs TNBC | LUMA vs HER2-E | LUMB vs TNBC | LUMB vs HER2-E | TNBC vs HER2-E | LUMA vs others | LUMB vs others | TNBC vs others | HER2-E vs others | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n = 25) | (n = 15) | (n = 15) | (n = 4) | |||||||||||||
| US sound transmission | p = 0.028 | p = 0.312 | p = 0.787 | p = 0.006 | p = 0.274 | p = 0.716 | p = 0.551 | p = 0.006 | p = 0.067 | p = 0.731 | ||||||
| Median (25th, 75th) | 1.00 (1.00, 3.00) | 2.00 (2.00, 4.00) | 1.00 (1.00, 2.00) | 2.00 (0.25, 3.00) | ||||||||||||
| IQR | 2.00 | 2.00 | 1.00 | − 2.75 | ||||||||||||
| OA/US internal vessel scores | p = 0.025 | p = 0.003 | p = 1.000 | p = 0.276 | p = 0.068 | p = 0.062 | p = 0.003 | p = 0.226 | p = 0.007 | p = 0.291 | ||||||
| Median (25th, 75th) | 2.0 (1.0, 2.0) | 2.0 (2.0, 3.0) | 3.0 (2.0, 5.0) | 2.0 (1.2, 2.0) | ||||||||||||
| IQR | 1.00 | 1.00 | 3.00 | 0.8 | ||||||||||||
| OA/US internal deoxygenated blush scores | p = 0.090 | p = 0.004 | p = 0.713 | p = 0.215 | p = 0.370 | p = 0.104 | p = 0.010 | p = 0.498 | p = 0.009 | p = 0.563 | ||||||
| Median (25th, 75th) | 1.0 (1.0, 2.5) | 2.0 (1.0, 3.0) | 3.0 (2.0, 4.0) | 2.0 (1.2, 2.0) | ||||||||||||
| IQR | 1.5 | 2.00 | 2.00 | 0.8 | ||||||||||||
| OA/US internal hemoglobin scores | p = 0.068 | p = 0.005 | p = 0.229 | p = 0.429 | p = 0.835 | p = 0.327 | p = 0.005 | p = 0.422 | p = 0.025 | p = 0.849 | ||||||
| Median (25th, 75th) | 1.0 (1.0, 2.0) | 2.0 (1.0, 4.0) | 3.0 (2.0, 4.0) | 2.0 (1.2, 2.7) | ||||||||||||
| IQR | 1.0 | 3.0 | 2.0 | 1.5 | ||||||||||||
| OA/US sum of 3 internal feature scores | p = 0.019 | p = 0.001 | p = 0.523 | p = 0.202 | p = 0.265 | p = 0.049 | p = 0.001 | p = 0.265 | p = 0.003 | p = 0.533 | ||||||
| Median (25th, 75th) | 4.0 (3.0, 7.0) | 7.0 (5.0, 9.0) | 8.0 (6.0, 12.0) | 5.5 (4.2, 6.8) | ||||||||||||
| IQR | 4.0 | 4.0 | 6.0 | 2.6 | ||||||||||||
| OA/US ratio sum of 3 internal/sum of 2 external feature scores | p = 0.164 | p = 0.006 | p = 0.373 | p = 0.074 | p = 0.961 | p = 0.530 | p = 0.013 | p = 0.909 | p = 0.011 | p = 0.808 | ||||||
| Median (25th, 75th) | 1.0 (0.4, 1.8) | 1.0 (0.7, 1.3) | 1.4 (0.8, 2.5) | 0.9 (0.9, 1.7) | ||||||||||||
| IQR | 1.4 | 0.6 | 1.7 | 0.8 | ||||||||||||
| OA/US sum of all 5 internal and external feature scores | p = 0.028 | p = 0.010 | p = 0.898 | p = 0.770 | p = 0.175 | p = 0.130 | p = 0.008 | p = 0.140 | p = 0.048 | p = 0.423 | ||||||
| Median (25th, 75th) | 11.0 (6.0, 14.5) | 14.0 (12.0, 19.0) | 15.0 (10.0, 18.0) | 11.5 (7.0, 14.5) | ||||||||||||
| IQR | 8.5 | 7.0 | 8.0 | 7.5 | ||||||||||||
p values generated by the Wilcoxon–Mann–Whitney U tests. The pairwise comparisons were only obtained for features that were found to be significant by the Kruskal–Wallis tests (Table 4)