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. 2019 Nov 5;7:34. doi: 10.1038/s41413-019-0070-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — MMP13^ocy−/− cortical bone displays hallmarks of suppressed perilacunar/canalicular remodeling. a–c Canalicular length in wild-type bone is longer than that in MMP13^ocy−/− bone in all regions sampled (b, n = 7), while lacunar area is not statistically different (c, n = 7). Graphs show mean ± SEM. d, e Collagen fiber organization is reduced in MMP13^ocy−/− bone (n = 9) compared with wild-type bone (n = 8) in the anterior quadrant but not in other regions. Lines represent the mean of all specimens in the group. Scale bars are 20 μm in a and 50 μm in d. *P < 0.05 between genotypes by unpaired t test