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. 2019 Nov 5;7:34. doi: 10.1038/s41413-019-0070-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Chondrocytes in MMP13^ocy−/− mice have altered cartilage matrix synthesis and MMP13 expression. a IHC of collagen II, aggrecan, and MMP13 in wild-type and MMP13^ocy−/− mice (sham group) show qualitative genotype-dependent changes in cartilage matrix synthesis and degradation, with apparent increases in collagen II and MMP13 and a decrease in aggrecan. b The collagen II to aggrecan ratio in MMP13^ocy−/− chondrocytes is significantly increased (n = 6). c The percentage of MMP13-positive chondrocytes in MMP13^ocy−/− knees is significantly increased (n = 10). Scale bars are 50 μm. Graphs show mean ± SD. *P < 0.05 between genotypes by unpaired t test