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. 2019 Nov 4;9:15927. doi: 10.1038/s41598-019-51799-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of NAPE-PLD deletion on NAPE and FAE levels in mouse striatum. (A,B) Levels of individual NAPEs in dorsal striatum of (A) wild-type (WT) mice, and (B) NAPE-PLD^−/− mice 48 h after intrastriatal 6-OHDA administration; open bars: control side of both WT and NAPE-PLD^−/− mice; color-coded bars: lesioned side of WT (blue) or NAPE-PLD^−/− (red) mice (n = 6–7). (C) Total NAPE levels in striatum of WT and NAPE-PLD^−/− (−/−); open bars: control side for both WT and NAPE-PLD^−/− mice; color-coded bars: lesioned side of WT (blue) or NAPE-PLD^−/− (red) mice (n = 6–7). (D) Levels of anandamide precursor NAPE (36:2–20:4) in striatum of WT and NAPE-PLD^−/− mice. Same color-coding as in (C) (n = 6–7). (E) SEA levels in striatum of WT and NAPE-PLD^−/− mice. Same color-coding as in (C) (n = 6–7). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 one-way ANOVA; °°°°P < 0.0001 two-way ANOVA, Bonferroni post hoc test.