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. 2019 Nov 4;9:15927. doi: 10.1038/s41598-019-51799-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of NAPE-PLD deletion on 6-OHDA-induced neurotoxicity in mouse SN. (A,B) Immunofluorescence images for TH in tissue sections of SN pars compacta: (A1,B1) control and (A2,B2) lesioned (ipsilateral and contralateral, respectively, to the 6-OHDA injection site) of wild-type (A1–2) or NAPE-PLD^−/− (B1-2) mice. Scale bar 200 µm. (C) Stereological count of TH⁺ neurons in SN pars compacta of WT and NAPE-PLD^−/− mice. Open bars: control side of both WT and NAPE-PLD^−/− mice; color-coded bars: lesioned side of WT (blue) or NAPE-PLD^−/− (red) mice (n = 3–4). ***P < 0.001 compared to intact contralateral side; °°P < 0.01 compared to lesioned side of wild-type mice, two-way ANOVA, Bonferroni post hoc test.