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. 2019 Nov 4;9:15927. doi: 10.1038/s41598-019-51799-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of siRNA-induced NAPE-PLD silencing on 6-OHDA induced neurotoxicity in SH-SY5Y cells. (A) Reactive oxygen species (ROS) and (B) active Caspase-3 (Casp3) in control and NAPE-PLD-silenced cells measured 8 and 6 h after 6-OHDA administration (n = 8 and 4 respectively). (C) Number of viable cells after 8 h of incubation with 6-OHDA. Results are expressed as percent of control cells treated with vehicle (n = 3). **P < 0.01, ***P < 0.001 compared to control; °P < 0.05, °°°P < 0.001 compared to scrambled cells treated with 6-OHDA, two-way ANOVA, Bonferroni post hoc test.