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. 2019 Nov 4;9:15910. doi: 10.1038/s41598-019-52210-9

Figure 5.

Figure 5

Myogenic srp expression leads to ectopic Laminin reporter activation and disrupted myogenesis. (A,A″′) Control animals show GFP reporter gene expression of LanB1 IE 3′ (A,A″ in green, A′,A″′ white) and Mef2-GAL4 driven UAS-lacZ activity (A,A″ blue) with anti-ß3Tubulin as muscles marker (red). (B,B″′) Ectopic expression of UAS-srpNC with Mef2-GAL4 is sufficient for Laminin reporter gene activation in somatic muscles (arrows) and unfused myoblasts (arrowheads), leading to disrupted myogenesis. GFP reporter gene expression (B,B″ green; B′,B″′ white) and anti-ß3Tubulin (red). Scale bars = 100 µm.