Table 3.

Protein targets for drug repositioning. E. granulosus H-PSCs up-regulated proteins for which there are available inhibitory drugs previously used for the treatment of different infections/diseases.

Target	Drug	Mechanism of action	Disease or pathogen treatable by the drug	Ref
Glycerol-3-phosphate dehydrogenase	Anacardic acids	Non-competitive enzyme inhibition	Tumors and Bacterial pathogens	108
Carbonyl reductase	Biphenyl compounds	Enzyme inhibition	Breast cancer	109
Cathepsin D	Amprenavira, Indinavira, Lopinavira, Nelfinavira, Ritonavira, Saquinavira	Enzyme inhibition	Human Immunodeficiency Virus Trypanosomatids: Leishmania species and T. cruzi	110, 111
Estradiol 17-beta dehydrogenase	Steroidal STX1040 and non-steroidal PBRM	Enzyme inhibition	Breast cancer	112
Glutathione-S-transferase	Ethacrynic acid analoguesa	Enzyme inhibition	Cancers	113
	Glutathione analogues: ezatiostat (TLK199)		Myelodysplastic syndrome	114
Proteasome subunits	Bortezomiba	Inhibition of p53 degradation?	Multiple myeloma	115
	Epoxomicin	Proteasome inhibition	Babesia divergens	116
	Carmaphycin B analogs	Proteasome inhibition	Plasmodium falciparum	117

^aFDA-approved drugs.