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. 2019 Nov 4;10(11):832. doi: 10.1038/s41419-019-2062-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Genomic distribution of GATA3 and UTX targets, based on ChIP-seq analysis. b Left: Venn diagram showing overlapping promoters bound by GATA3 and UTX in MCF-7 cells. Right: pathway analysis of 202 overlapping target genes of GATA3 and UTX arranged into functional groups. c MEME-ChIP analysis of GATA3- and UTX-bound motifs. d Verification of ChIP-seq results through qChIP analysis of indicated genes in MCF-7 cells. Results are expressed as fold-change relative to control, and GAPDH was used as a negative control. Data are shown as means ± SD from three independent experiments. e qPCR and western blotting analysis of the expression of UTX and Dicer in GATA3- or UTX-depleted MCF-7 cells. f qPCR and western blotting analysis of the expression of UTX and Dicer in GATA3- or UTX-overexpressing MDA-MB-231 cells. d–f Two-tailed unpaired t test (*p < 0.05, **p < 0.01, ***p < 0.001)