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. 2019 Nov 4;10(11):837. doi: 10.1038/s41419-019-2063-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic of calcium and TRAIL-mediated apoptosis. Dark red coloring indicates additions to the computational model. b Apoptosis or cPARP concentration of cancer cells treated with TRAIL with or without Yoda1. Dashed line represents the threshold of cPARP at which cancer cells are considered apoptotic. c Time of MOMP determined by release of Smac, which follows MOMP for cancer cells treated with TRAIL with or without Yoda1. d Apoptosis of cancer cells treated with Yoda1 with or without TRAIL. e Time of MOMP of cancer cells treated with Yoda1 with or without TRAIL