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. 2019 Nov 4;9:15948. doi: 10.1038/s41598-019-52350-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bisphenol A (BPA) or S (BPS) rapidly decreases left ventricular function in male mice. Hearts excised from male CD1 mice were perfused with BPA (1 nM), BPS (1 nM), BPS + PHTPP (1 μM), or vehicle (0.0001% ethanol, Control) using a Langendorff apparatus. Functional parameters measured were (A) LVESP; (B) LVEDP; (C) Maximum rate of contraction; and (D) Rate of relaxation. Key: LVESP, left ventricular end systolic pressure; LVEDP, left ventricular end diastolic pressure; dP/dt_max, maximum rate of contraction; dP/dt_min, maximum rate of relaxation; PHTPP, estrogen receptor-β anatagonist. N = 10 for all groups except N = 6 for BPS + PHTPP. Values presented are mean ± SEM. ^ap < 0.05 vs baseline of same group; ^bp < 0.05 vs BPA; ^cp < 0.05 vs same treatment and time in females.