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. 2019 Nov 4;9:15948. doi: 10.1038/s41598-019-52350-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cardiac myofilament function is not affected by bisphenol A (BPA) or S (BPS) in mice of either sex. Hearts excised from male and female CD1 mice were perfused with BPA (1 nM), BPS (1 nM), BPS + PHTPP (1 μM), or vehicle (0.0001% ethanol, Control) using a Langendorff apparatus. Cardiac myofilaments were isolated and function assessed using an actomyosin MgATPase assay. (A) Actomyosin MgATPase-calcium curves; (B) Actomyosin MgATPase EC₅₀ values after; and (C) Hill coefficients of actomyosin MgATPase-calcium curves with BPA or BPS treatment of hearts from female mice. (D) Cardiac actomyosin MgATPase-calcium relationships; (E) Actomyosin MgATPase EC₅₀ values; and (F). Hill coefficient of myofilaments isolated from hearts of male mice following BPA or BPS treatment. N = 10 for all groups. Values presented are mean ± SEM.