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. 2019 Nov 4;9:15948. doi: 10.1038/s41598-019-52350-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bisphenol A (BPA) but not bisphenol S (BPS) alter cardiac myofilament phosphorylation in male mouse hearts. Hearts from male CD1 mice were perfused for 15 min with BPA (1 nM), BPS (1 nM), or vehicle (0.0001% ethanol, Control). (A) Isolated cardiac myofilament proteins were separated with 12% SDS-PAGE and phosphorylated proteins detected using Pro-Q Diamond phosphoprotein stain (left). Coomassie stain was used to determine total protein load (right). (B) Quantification of cardiac myofilament protein phosphorylation changes. Representative samples from the same gel are presented. Key: MyBP-C, myosin binding protein C; TnT, troponin T, Tm, tropomyosin; TnI, troponin I. N = 10 per group. Values presented are mean ± SEM. ^ap < 0.05 vs baseline of same group; ^bp < 0.05 vs BPA; ^cp < 0.05 vs same treatment and time in females.