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. 2019 Nov 4;9:15948. doi: 10.1038/s41598-019-52350-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bisphenol A (BPA) and bisphenol S (BPS) differentially affect phospholamban (PLB) phosphorylation in a sex-dependent manner. Hearts from female and male CD1 mice were perfused for 15 min with BPA (1 nM), BPS (1 nM), or vehicle (0.0001% ethanol, Control). Myocardial homogenates were probed with antibodies for phosphorylated phospholamban (PLB) at serine 16 (S16) or threonine 17 (T17). S16 phosphorylation in samples from female (A) and male (B) hearts. T17 phosphorylation in both sexes. (C,D) Total PLB levels in both sexes. (E,F) Representative samples from the same membranes are presented. N = 8 in each group for each sex. Values presented are mean ± SEM. ^ap < 0.05 vs baseline of same group; ^bp < 0.05 vs BPA; ^cp < 0.05 vs same treatment and time in females.