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. 2019 Nov 4;9:15966. doi: 10.1038/s41598-019-52428-7

Table 3.

Comparison of mean changes of the NIRS variables between groups regarding the treadmill test, before and after the intervention.

Variables Conventional Group Modified Group Effect group
(p-value)
Effect situation
(p-value)
Effect Interaction
(p-value)
Pre (n = 20) Post (n = 16) Pre (n = 20) Post (n = 16)
Delta HHb on treadmill (a.u.)

11.87

(7.96 to 15.78)

12.04

(6.75 to 17.34)

12.49

(8.67 to 16.31)

12.34

(7.18 to 17.5)

0.870 0.995 0.932
Delta StO2 on treadmill (%)

−19.09

(−22.77 to −15.41)

−18.00

(−22.30 to −13.69)

−21.07

(−24.65 to −17.49)

−21.29

(−25.47 to −17.11)

0.288 0.709 0.575
Time to reach lower StO2 on treadmill (s)

150.00

(109.72 to 190.28)

772.00*,†

(423.11 to 1120.89)

104.00

(64.74 to 143.26)

140.63

(−197.19 to 478.44)

0.008 0.010 0.020
Time of resistance after reaching lower StO2 (s)

133.16

(41.31 to 225.01)

1236.00*

(487.78 to 1984.22)

147.50

(57.98 to 237.02)

1250.00*

(525.54 to 1974.46)

0.956 <0.001 0.999
Recovery time on the treadmill (s)

720.68

(316.68 to 1124.68)

155.08*

(72.54 to 237.62)

637.76

(210.66 to 1064.86)

223.77*

(146.56 to 300.98)

0.962 0.002 0.610
Deoxygenation Rate (∆StO2/s)

0.19

(−2.60 to 2.99)

0.09*,†

(−1.73 to 1.91)

0.25

(−3.73 to 4.22)

0.20*

(−1.29 to 1.7)

0.017 0.002 0.185
Re-oxygenation Rate (∆StO2/min)

−3.75

(−5.1 to −2.40)

−3.26

(−7.19 to 0.67)

−4.32

(−5.69 to −2.95)

−5.26

(−9.33 to −1.19)

0.375 0.870 0.601
Relative re-oxygenation rate (∆StO2/min)

−11.90

(−21.82 to −1.98)

−114.17*

(−204.4 to −23.93)

−17.69

(−28.63 to −6.76)

−78.24*

(−171.88 to − 5.4)

0.639 0.017 0.517
Walking economy meters/delta HHb (m/∆HHb)

16.61

(−35.35 to 68.56)

3.29

(−511.54 to 518.11)

−11.24

(−61.89 to 39.4)

−37.25

(−535.72 to 461.23)

0.847 0.912 0.972
Walking economy meters/delta StO2 (m/∆StO2)

−11.52

(−17.84 to −5.20)

−127.82*

(−185.90 to −69.75)

−10.06

(−16.22 to −3.90)

−57.80*

(−112.12 to −3.47)

0.078 <0.001 0.090

Data are presented as mean (95% CI). HHb: deoxyhemoglobin; a.u.: arbitrary unit; StO2: tissue saturation; s: seconds, ∆: delta/variation; *p < 0.05 for comparison between pre and post treatment, via Bonferroni test; p < 0.05 for comparison between groups, via Bonferroni test.