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. 2019 Oct 29;10:739. doi: 10.3389/fendo.2019.00739

Table 1.

Patient data of the 123 samples included.

Sample Diagnosis Cohort Age at diagnosis (range) Tumor size (mm), laterality Aldosterone AVS right nmol/L Aldosterone AVS left nmol/L Cortisol AVS right nmol/L Cortisol AVS left nmol/L Lateralization index Date of sampling
1 BAH NGS 40–45 15, right 22.27 43.63 62.39 127.6 1.04 2018
2 BAH NGS 60–65 Normal 16.68 12.69 177.55 121.33 0.9 2018
3 BAH NGS 30–35 12, left 24.52 9.47 67.61 22.8 0.87 2018
4 BAH NGS 56–60 10, right 14.9 9.35 75.55 52.13 1.1 2018
5 BAH NGS 36–40 Normal 15.31 12.17 175.13 99.11 0.71 2018
6 BAH NGS 36–40 Normal 55.12 54.66 126.37 115.2 0.92 2018
7 BAH NGS 40–45 Normal 26.42 20.8 339.67 157.47 0.59 2018
8 BAH NGS 56–60 Normal 23.37 14.92 160.04 84.86 0.83 2018
9 BAH NGS 65–70 Normal 7.82 7.13 99.8 83.96 0.92 2018
10 BAH NGS 46–50 10/19, right/left 103.76 42.45 326.61 225.48 1.69 2017
11 BAH NGS 60–65 9/7, right/left 44.39 47.16 176.54 144.64 0.77 2016
12 BAH NGS 70–75 5/15, right/left 835.06 882.23 387.88 249.76 0.61 2015
13 BAH NGS 66–70 5/5, right/left 174.78 66.58 256.29 92.08 0.94 2015
14 BAH NGS 50–55 16, left 9.61 6.39 221.49 167.48 1.14 2016
15 APA NGS 70–75 Normal 1.36 24.33 35.53 17.4 0.03 2018
16 APA NGS 86–90 15, right 31.34 1.32 6.89 6.53 22.58 2013
17 APA NGS 40–45 12, left 0.39 38.9 245.05 276.23 0.01 2013
18 APA NGS 56–60 12, left 57.24 5.28 85.19 193.94 24.68 2014
19 APA NGS 46–50 15, right 20.3 4.4 108.03 160.23 6.85 2014
20 APA NGS 40–45 10, left 1.25 225 6.89 12.33 0.01 2014
21 APA NGS 50–55 Normal 5.09 236 469.8 482.85 0.02 2016
22 APA NGS 56–60 8, right 1170.76 9.93 327.7 248.68 89.45 2017
23 APA NGS 30–35 14, right 108.2 2 97.15 27.55 15.36 2017
24 APA NGS 56–60 29, right 78.51 2.64 271.51 81.56 8.95 2015
25 APA NGS 46–50 5/5, right/left 33.29 169.23 416.88 160.23 0.08 2017
26 APA NGS 40–45 10, right 1942.01 6.94 369.75 179.08 135.61 2017
27 APA NGS 50–55 5/10, right/left 0.39 310.72 5.44 207.71 0.05 2016
28 APA NGS 46–50 7/9, right/left 61.03 4.72 315.01 122.16 5.02 2015
29 APA NGS 56–60 6/7, right/left 55.49 124.84 213.51 88.45 0.18 2016
30 APA NGS 60–65 12, left 30.52 63.81 219.31 96.43 0.21 2017
31 BAH Validation 40–45 Normal 41.07 13.69 539.04 214.6 1.19 2018
32 BAH Validation 30–35 Normal 48.49 21 390.78 181.98 1.08 2018
33 BAH Validation 40–45 Normal 37.79 13.6 192.13 101.86 1.47 2018
34 BAH Validation 70–75 26, left 65.99 17.58 553.9 193.21 1.31 2018
35 BAH Validation 60–65 23, left 5.05 38.09 22.48 170.01 1 2018
36 BAH Validation 46–50 Normal 33.69 39.79 328.79 161.31 0.42 2018
37 BAH Validation 35–40 Normal 50.19 41.29 234.9 312.84 1.62 2018
38 BAH Validation 60–65 2, left 18.3 14.55 174 104.76 0.76 2018
39 BAH Validation 50–55 20, right 6.49 3.9 94.25 106.58 1.88 2014
40 BAH Validation 36–40 20, right 0.33 1.08 4.21 7.21 0.52 2015
41 BAH Validation 66–70 7, left 3.28 5.68 48.58 36.61 0.44 2018
42 BAH Validation 60–65 Normal 0.5 17.37 15.23 199.01 0.38 2014
43 BAH Validation 46–50 Normal 1.04 3.38 19.21 56.91 0.91 2014
44 BAH Validation 56–60 Normal 66.03 5.58 537.23 55.46 1.22 2014
45 BAH Validation 50–55 15, left 4.77 13.07 20.3 89.18 1.6 2015
46 BAH Validation 40–45 10, left 0.69 22.86 17.04 711.96 1.26 2015
47 BAH Validation 56–60 Normal 1.44 1.56 21.39 20.3 0.87 2015
48 BAH Validation 46–50 Normal 3.72 107.2 67.06 1255.71 0.65 2016
49 BAH Validation 50–55 Normal 17.01 30.93 176.9 344.74 1.07 2016
50 BAH Validation 56–60 Normal 2.63 3.97 6.89 11.24 1.08 2015
51 BAH Validation 40–45 Normal 9.73 7.74 10.88 17.04 1.97 2013
52 BAH Validation 40–45 Normal 2.8 4.26 40.24 95.34 1.56 2013
53 BAH Validation 36–40 Normal 6.18 1.04 233.09 27.91 0.71 2012
54 BAH Validation 56–60 7, right 4.43 12.13 117.09 208.8 0.65 2012
55 BAH Validation 50–55 Normal 4.82 15.58 199.01 362.5 0.56 2011
56 BAH Validation 30–35 Normal 6.46 1.14 83.05 19.68 1.35 2011
57 BAH Validation 40–45 Left 1.3 cm 1.62 36.62 40.6 347.28 0.38 2011
58 BAH Validation 60–65 Normal 15.05 9.95 47.96 61.66 1.94 2010
59 BAH Validation 40–45 10, left 5.27 53.82 11.64 242.19 2.04 2010
60 BAH Validation 45–50 Normal 3.68 2.44 206.01 244.47 1.79 2010
61 BAH Validation 36–40 Normal 12.06 1.95 10.95 4.82 2.73 2011
62 BAH Validation 56–60 10, right 10.61 10.85 1382.95 1027.7 0.73 2011
63 BAH Validation 50–55 Normal 2.5 5.52 52.24 69.78 0.6 2014
64 BAH Validation 70–75 Normal 2.66 2.27 7.54 10.19 1.58 2011
65 BAH Validation 50–55 22/11, right/left 5.31 16.92 6.45 7.29 0.35 2013
66 BAH Validation 50–55 Normal 13.57 8.54 44.95 33.02 1.17 2014
67 BAH Validation 66–70 5, left 92.8 89.2 696.37 234.54 0.35 2018
68 BAH Validation 60–65 7, left 35.6 18.22 416.88 199.74 0.94 2016
69 BAH Validation 36–40 14/20, right/left 83.5 13.2 508.95 181.61 2.26 2018
70 BAH Validation 66–70 15/10, right/left 4.4 1.7 411.08 235.63 1.48 2018
71 BAH Validation 66–70 Normal 43.35 21.2 411.44 180.89 0.9 2018
72 BAH Validation 66–70 7, right 54.5 43.2 317.19 85.19 0.34 2019
73 BAH Validation 66–70 Normal 99.87 58.26 511.13 291.81 0.98 2018
74 BAH Validation 36–40 Normal 180.33 21.08 913.51 296.89 2.78 2018
75 BAH Validation 36–40 5, left 44.39 23.03 114.91 93.16 1.56 2018
76 BAH Validation 40–45 11, left 11.08 12.07 101.14 128.33 1.16 2019
77 BAH Validation 50–55 15, right 44.08 15.08 247.73 179.77 2.12 2019
78 APA Validation 60–65 13, left 125.98 2.12 355.98 437.54 73.05 2018
79 APA Validation 50–55 20, left 4.82 25.63 330.96 173.28 0.1 2018
80 APA Validation 20–25 7, left 25.2 47.39 808.02 272.24 0.18 2018
81 APA Validation 50–55 18, left 7.2 20.8 238.53 61.63 0.09 2018
82 APA Validation 46–50 23/23, right/left 0.84 47.83 39.51 197.2 0.09 2018
83 APA Validation 60–65 10, left 5.92 48.19 175.09 69.6 0.05 2018
84 APA Validation 56–60 10, left 16.9 14.8 379.54 84.46 0.25 2018
85 APA Validation 56–60 Normal 19.3 41.19 630.03 339.3 0.25 2018
86 APA Validation 30–35 15, right 18.34 261.18 116.98 70.72 0.04 2018
87 APA Validation 40–45 20, left 6.63 97.74 191.8 146.89 0.05 2018
88 APA Validation 56–60 15, right 393.95 17.37 184.51 177.99 21.88 2015
89 APA Validation 56–60 6/8, right/left 10.26 277.43 193.21 317.91 0.06 2015
90 APA Validation 40–45 10, right 163.68 3.99 164.94 122.89 30.53 2016
91 APA Validation 30–35 14, right 108.2 2 97.15 27.55 15.36 2017
92 APA Validation 46–50 10/15, right/left 1.69 88.78 127.96 124.34 0.02 2017
93 APA Validation 66–70 12, right 5.55 33.29 192.49 126.51 0.11 2017
94 APA Validation 56–60 13, left 8.6 244.14 140.65 95.34 0.02 2017
95 APA Validation 56–60 10/5, right/left 177.56 11.93 314.29 287.1 13.6 2017
96 APA Validation 50–55 Normal 0.63 6.61 56.91 14.61 0.02 2014
97 APA Validation 50–55 Normal 50.62 5.93 80.84 266.08 28.11 2014
98 APA Validation 56–60 16, right 64.6 1.67 174 268.25 59.63 2017
99 APA Validation 46–50 15, right 160 1.55 12.14 35.71 303.35 2017
100 APA Validation 36–40 13, left 5.33 62.01 219.68 175.09 0.07 2015
101 APA Validation 66–70 Normal 15.98 1.13 15.95 104.76 92.96 2014
102 APA Validation 30–35 13, right 14.32 1.32 28.64 86.28 32.8 2017
103 APA Validation 50–55 Normal 232.6 0.62 7.98 5.8 273.43 2016
104 APA Validation 60–65 Normal 25.52 1.31 17.76 63.8 70.16 2014
105 APA Validation 60–65 20, left 1.12 38.51 12.83 24.14 0.05 2010
106 APA Validation 56–60 hyperplasia 8.73 7.47 527.44 17.33 0.04 2010
107 APA Validation 56–60 20/15, right/left 41.76 8.28 572.75 8.59 0.08 2011
108 APA Validation 36–40 Hyperplasia 1.49 6.33 10.66 9.68 0.21 2013
109 APA Validation 50–55 40, left 1.35 49.07 78.3 119.63 0.04 2012
110 APA Validation 56–60 Normal 0.83 97.93 350.18 209.89 0.01 2014
111 APA Validation 46–50 20, left 1.12 44.72 185.31 210.83 0.03 2015
112 APA Validation 40–45 Normal 9.73 7.74 10.95 16.97 1.95 2013
113 APA Validation 36–40 16, right 133.12 0.35 180.13 42.74 91.08 2009
114 APA Validation 26–30 16, left 3.16 20.91 696.73 441.17 0.1 2011
115 APA Validation 56–60 12/5, right/left 280.2 10.71 254.11 205.54 21.16 2018
116 APA Validation 46–50 14, left 8.46 372.42 398.03 379.9 0.02 2018
117 APA Validation 36–40 6/11, right/left 9.99 99.87 225.48 204.45 0.09 2018
118 APA Validation 60–65 5/12, right/left 19.7 55.49 265.35 163.49 0.22 2018
119 APA Validation 50–55 14/13, right/left 61.03 224.72 179.8 84.1 0.13 2018
120 APA Validation 56–60 9/5, right/left 1417.67 3.83 226.56 82.29 134.49 2019
121 APA Validation 46–50 18, left 22.97 41.71 89.14 33.42 0.21 2019
122 APA Validation 66–70 21, right 55.83 1.34 70.76 31.39 18.52 2019
123 APA Validation 60–65 normal 116.48 19.41 195.21 134.49 4.13 2019

APA, aldosterone-producing adenoma; AVS, adrenal vein sampling; BAH, bilateral adrenal hyperplasia.