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. 2019 Oct 29;10:1367. doi: 10.3389/fphys.2019.01367

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Copyright © 2019 Hung, Kanke, Kurtz, Cubitt, Bunaciu, Zhou, White, Vickers, Hussain, Li and Sethupathy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of LNA29 on lipogenesis genes are shared with that of BT2 compound known to reduce liver fat partly through the suppression of miR-29. (A) Expressions of lipogenesis genes which are downregulated in LNA29-treated WT/Floxed mice in ZFR compared to ZLR (upper panel) and in ZFR upon BT2 treatment (lower panel). (B) Expressions of FAO genes which are downregulated in LNA29-treated L-Sirt1 KO mice are in ZFR compared to ZLR (upper panel) and in ZFR upon BT2 treatment (lower panel). FAO, fatty acid oxidation, ZFR, Zucker Fatty rat, ZLR, Zucker Lean rat. ^∗P < 0.05 and ^#P < 0.001 by two tailed Students’ t test after Bonferroni correction (ZFR, n = 4; ZLR, n = 4; Vehicle, n = 4; BT2, n = 4).