Table 4.
Association of patient satisfaction scales at 4 weeks with subsequent early study drug discontinuation
| Questionnaire/Scale | Cut-offa | Not satisfiedb | Satisfiedb | HR (95% CI)c Not satisfied vs. satisfied | P valuec |
|---|---|---|---|---|---|
| ACTS | |||||
| Burdens | |||||
| N | 42 | 29 | 1152 | ||
| Events/100 pt-years (total events) | 6.89 (4) | 5.41 (112) | 1.44 (0.44–3.46) | 0.50 | |
| Benefits | |||||
| N | 12 | 462 | 719 | ||
| Events/100 pt-years (total events) | 6.02 (51) | 5.07 (65) | 1.18 (0.81–1.71) | 0.38 | |
| TSQM II | |||||
| Effectiveness | |||||
| N | 67 | 195 | 986 | ||
| Events/100 pt-years (total events) | 7.00 (23) | 5.16 (93) | 1.23 (0.76–1.91) | 0.38 | |
| Side Effects | |||||
| N | 100 | 326 | 855 | ||
| Events/100 pt-years (total events) | 5.55 (31) | 5.41 (85) | 0.99 (0.64–1.48) | 0.95 | |
| Convenience | |||||
| N | 67 | 98 | 1083 | ||
| Events/100 pt-years (total events) | 4.61 (8) | 5.52 (108) | 0.77 (0.34–1.48) | 0.48 | |
| Global Satisfaction | |||||
| N | 67 | 149 | 1032 | ||
| Events/100 pt-years (total events) | 5.32 (14) | 5.47 (102) | 0.95 (0.52–1.61) | 0.86 | |
ACTS Anti-Clot Treatment Scale, CI confidence interval, HR hazard ratio, TSQM II Treatment Satisfaction Questionnaire for Medication version II
aSatisfaction is defined as a score at or above the cut-off
bGroups are defined using “satisfied” or “not satisfied” survey answers (primary analysis; see Methods)
cHazard ratio and P value for discontinuation are from adjusted model