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Histology of DITRA shows epidermal acantosis with edema and dilated blood vessels in the papillary dermis. There is epidermal spongiosis with the presence of neutrophils migrating through the epidermis (A,B). In the most superficial part of the epidermis (inset-B) there is a subcorneal pustule that is formed through the aggregation of neutrophilic spongiform pustules.
