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. 2019 Nov 4;9:15940. doi: 10.1038/s41598-019-52367-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Katanin p60 regulates neuronal progenitor positioning during corticogenesis. (A–C) E15 in utero electroporation followed by E19 analysis revealed a significant increase of pCAG-Venus-positive cells at the ventricular/subventricular zone of the developing cortex. Non-parametric T-test (Two-tailed). (+/+) n = 4, 16 sections; (+/−) n = 7, 26 sections. For Bin 6 (+/+) = 11.53% ± 1.81%; (+/−) = 15.64%±0.88%. Data represented as mean ± S.E.M. *p < 0.05. (D) DAPI staining at E19. (E) Accumulating cells display a rounded shape in contrast to the typical bipolar shape of migrating cells. (F) DCX-positive cells display normal RMS migration in adult animals. [Boxed regions are enlarged and show comparable positioning of DCX-positive cells between the two genotype groups]. (G) In contrast to stage E19, Cux1 and Ctip2 staining in sagittal sections of young adult mice show comparable layering between genotypes.