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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Neuroendocrinol. 2019 May 23;32(1):e12724. doi: 10.1111/jne.12724

Figure 3.

Figure 3.

Estradiol regulation of firing rate and EPSC frequency in kisspeptin neurons of the hypothalamus. A. AVPV kisspeptin neuron firing rate is elevated during proestrus (left) and by estradiol (right). Open symbols in OVX+E were injected with vehicle at the time of progestin injection, closed symbols were uninjected controls. B, C. Spontaneous glutamatergic EPSC frequency is regulated by cycle stage and estradiol in both AVPV (B) and arcuate (C) kisspeptin neurons. Estradiol regulation is lost in KERKO mice. From (93,98) with permission.