Table 4.

Pooled multivariable analysis and lasso regression of joint infiltration by all leukocytes.

	Joint Multicellular			LASSO
Covariates*	Effect	95% CI	P	Effect	95% POSI	P
Immature B	1.815	(0.682, 2.948)	0.002	1.808	(0.593, 2.942)	0.003
Plasma B	2.276	(0.822, 3.731)	0.002	2.267	(0.339, 4.653)	0.012
Memory B	−2.081	(−3.622, −0.539)	0.009	−2.072	(−3.668, 0.807)	0.069
Monocyte	−1.271	(−2.615, 0.073)	0.065	−1.266	(−2.64, 0.439)	0.064
Activated NK	−1.216	(−2.669, 0.237)	0.102	−1.211	(−2.704, 0.776)	0.102
CD4	−1.002	(−2.212, 0.207)	0.106	−0.998	(−2.213, 0.683)	0.107
Dendritic	−1.053	(−2.331, 0.225)	0.108	−1.049	(−3.014, 0.709)	0.104
CD8	0.814	(−0.515, 2.143)	0.231	0.811	(−1.537, 2.984)	0.227
Granulocyte	0.654	(−0.598, 1.906)	0.307	0.651	(−1.888, 1.888)	0.315
NK	−0.572	(−2.02, 0.876)	0.439	−0.570	(−2.17, 3.146)	0.443
Naïve B	−0.358	(−1.837, 1.12)	0.635	−0.357	(−1.694, 5.878)	0.657
Treg	0.215	(−1.23, 1.66)	0.771	0.214	(−10.105, 1.386)	0.788
Age	−0.147	(−0.297, 0.004)	0.058	−0.965	(−1.958, 0.284)	0.058
Race
Not White	0.450	(−2.156, 3.056)	0.735	0.180	(−5.808, 1.077)	0.740
Gender
Female	−2.586	(−4.795, −0.377)	0.023	−1.248	(−2.315, −0.028)	0.023
Cohort
GSE67024	2.875	(−0.347, 6.097)	0.082	0.934	(−0.452, 2.708)	0.080
GSE61450	14.117	(11.78, 16.454)	1.9E-25	6.433	(5.383, 8.842)	0

CI: confidence interval; POSI: post-selection interval

^*Italicized cell types indicate cell types that were selected in the active set by LASSO.