Table 5. Cumulative infiltration by multiple cell-types and BMI.

Cumulative mED (cmED) scores, weighted by cell-specific effect estimates obtained from the pooled data, are associated with BMI across all cohorts, and after pooling.

	Full Panela				Validated CTsb				Joint-Lasso CTsc
	Effect	SE	P	${\mathit{R}}_m^2$	Effect	SE	P	${\mathit{R}}_m^2$	Effect	SE	P	${\mathit{R}}_m^2$
LEAP	1.136	0.210	2.7E-07	0.175	0.710	0.254	0.006	0.051	1.135	0.204	1.4E-07	0.177
GSE67024	0.881	0.232	3.2E-04	0.128	1.630	0.455	0.001	0.142	1.051	0.250	7.9E-05	0.159
GSE61450	1.761	0.394	1.4E-04	0.427	2.545	0.446	5.3E-06	0.540	1.761	0.394	1.4E-04	0.427
Pooled*	2.058	0.503	5.9E-05	0.423	0.882	0.525	0.094	0.394	1.752	0.508	0.001	0.412

Panels for each cmED analysis included:

^aall twelve cell-types

^bCD4, monocytes, and dendritic cell-types

^cimmature B, plasma B, Memory B, monocytes, aNK, CD4, dendritic, CD8, granulocytes, and NK cell-types.

SE: standard error;${\mathit{R}}_m^2$: marginal R-squared value; CTs: cell-types

^*includes a cohort effect in the model.