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. Author manuscript; available in PMC: 2021 Feb 15.
Published in final edited form as: Int J Cancer. 2019 May 20;146(4):953–969. doi: 10.1002/ijc.32390

Table 3:

Multivariate associations with endemic Burkitt lymphoma the EMBLEM Study, 2010–2016.

Uganda Tanzania Kenya All countries combined
Characteristics aOR* (95% CI) aOR* (95% CI) aOR* (95% CI) aOR* (95% CI)
Season
  Dry Ref Ref Ref Ref
  Wet 2.54 (1.67, 3.86) 1.51 (0.79, 2.86) 0.28 (0.18, 0.45) 1.28 (0.99, 1.66)
  p-value <0.0001 0.211 <0.0001 0.058
Measure of malaria
 Indoor residual insecticide sprayed in house
  No Ref Ref Ref Ref
  Yes 1.71 (1.07, 2.73) 3.93 (2.03, 7.62) 6.78 (3.51, 13.10) 2.32 (1.75, 3.09)
  p-value 0.026 <0.0001 <0.0001 <0.0001
 Mosquito net ownership and use the night before
  No Ref Ref Ref Ref
  Yes, but not used 39.7 (13.3, 118) 4.09 (1.25, 13.35) 5.74 (2.48, 13.3) 9.23 (5.59, 15.24)
  Yes, and used 4.12 (2.64, 6.42) 1.32 (0.60, 2.90) 1.47 (0.86, 2.53) 2.36 (1.76, 3.18)
  p-value <0.0001 0.058 0.0002 <0.0001
 Regularly uses mosquito insecticide sprays
  No Ref Ref Ref
  Yes 5.62 (1.85, 17.01) 3.47 (1.16, 10.37) 2.97 (1.65, 5.32)
  p-value 0.002 0.026 0.0003
 Malaria rapid diagnostic test
  Negative Ref Ref Ref Ref
  Positive 0.43 (0.28, 0.68) 0.56 (0.27, 1.16) 0.33 (0.20, 0.55) 0.46 (0.35, 0.60)
  p-value 0.0003 0.120 <0.0001 <0.0001
History of fevers, and malaria treatment
 ≥1 fever due to malaria up to 6 months before enrollment
  No Ref Ref Ref
  Yes 0.48 (0.29, 0.77) 0.59 (0.35, 0.98) 0.63 (0.47, 0.84)
  p-value 0.003 0.042 0.001
 ≥1 fever not due to malaria up to 6 months before enrollment
  No Ref Ref Ref Ref
  Yes 8.82 (5.37, 14.49) 3.88 (2.05, 7.36) 6.98 (4.39, 11.09) 5.66 (4.31, 7.42)
  p-value <0.0001 <0.0001 <0.0001 <0.0001
 ≥1 hospital admission
  No Ref Ref
  Yes 21.29 (9.61, 47.17) 9.35 (6.85, 12.77)
  p-value <0.0001 <0.0001
 Inpatient malaria treatment
  Yes, past 12 months Ref Ref Ref Ref
  Yes, > 12 months 3.97 (1.66, 9.51) 2.89 (0.80, 10.41) 0.18 (0.07, 0.48) 0.99 (0.62, 1.57)
  Never 3.41 (1.52, 7.67) 26.43 (7.73, 90.36) 0.48 (0.25, 0.91) 5.59 (3.61, 8.66)
  p-value 0.007 <0.0001 0.003 <0.0001
 Outpatient malaria treatment
  Yes, past 12 months Ref Ref Ref Ref
  Yes, > 12 months 2.17 (1.17, 4.03) 0.45 (0.14, 1.48) 1.61 (0.70, 3.72) 2.23 (1.50, 3.31)
  Never 0.59 (0.35, 0.99) 0.54 (0.27, 1.07) 1.48 (0.87, 2.53) 0.96 (0.71, 1.29)
  p-value 0.0001 0.154 0.277 <0.0001
Parental characteristics
 Mother’s education
  Up to standard 4 Ref Ref
  Standard 5–7 0.81 (0.52, 1.26) 0.81 (0.60, 1.08)
  ≥ Senior secondary school 0.46 (0.19, 1.12) 0.77 (0.50, 1.20)
  p-value 0.197 0.319
  p-trend 0.082 0.227
 Father’s education
  Up to standard 4 Ref  Ref Ref Ref
  Standard 5–7 0.75 (0.44, 1.26) 0.25 (0.11, 0.55) 1.13 (0.54, 2.37) 0.71 (0.51, 1.00)
  ≥ Senior secondary school 0.53 (0.28, 0.99) 0.19 (0.05, 0.68) 1.03 (0.49, 2.17) 0.70 (0.47, 1.04)
  p-value 0.136 0.002 0.908 0.116
  p-trend 0.033 0.002 0.943 0.068
 Mother’s occupation
  Trader/Sales Ref  Ref Ref Ref
  Peasant farmer 0.64 (0.23, 1.75) 0.47 (0.17, 1.34) 2.80 (1.53, 5.11) 1.31 (0.86, 1.97)
  Manual laborer 0.79 (0.19, 3.21) 0.75 (0.18, 3.02) 2.36 (1.07, 5.22) 1.54 (0.89, 2.69)
  p-value 0.668 0.334 0.004 0.272
 Mother’s income, US dollars§
  7.5 Ref  Ref Ref Ref
  7.6-≤15.0 0.97 (0.60, 1.58) 0.68 (0.31, 1.46) 0.78 (0.42, 1.43) 0.88 (0.65, 1.20)
  >15.0 0.27 (0.14, 0.52) 0.20 (0.08, 0.47) 0.70 (0.40, 1.24) 0.46 (0.33, 0.64)
  p-value 0.0004 0.001 0.468 <0.0001
  p-trend 0.0003 0.001 0.249 <0.0001
Home characteristics
 Distance of home from main road
  Far from the main road  Ref Ref Ref
  Near the main road 4.33 (2.00, 9.37) 1.88 (1.15, 3.07) 1.66 (1.23, 2.24)
  In town or city 9.17 (2.84, 29.63) 1.94 (0.97, 3.90) 2.92 (1.83, 4.67)
  p-value <0.0001 0.026 <0.0001
 Number of rooms in house
  1–2 room  Ref Ref Ref
  ≥ 3 rooms 1.33 (0.67, 2.65) 1.46 (0.91, 2.33) 1.19 (0.88, 1.62)
  p-value 0.419 0.117 0.256
 Number of children and adult resident
  2–4 people Ref Ref Ref
  5–7 people 1.51 (0.99, 2.31) 1.12 (0.49, 2.58) 1.23 (0.92, 1.66)
  ≥ 8 people 1.47 (0.62, 3.49) 1.35 (0.56, 3.29) 1.21 (0.81, 1.80)
  p-value 0.144 0.788 0.365
  p-trend 0.08  0.497 0.428
 Number of people sleeping in the same room as child
  0–2 people Ref Ref
  3 people 1.27 (0.75, 2.16) 1.42 (1.02, 1.97)
  ≥ 4 people 1.10 (0.63, 1.93) 1.31 (0.94, 1.84)
  p-value 0.673 0.109
  p-trend 0.649 0.177
 Source of drinking water
  Unprotected spring/well Ref Ref
  Protected spring/well 1.44 (0.82, 2.53) 1.53 (1.11, 2.10)
  Public tap/piped household 0.97 (0.53, 1.76) 1.08 (0.72, 1.63)
  p-value 0.395 0.032
 Distance to water source, meters
  < 500 Ref Ref Ref Ref
  500–999 5.58 (2.81, 11.08) 0.32 (0.13, 0.78) 0.57 (0.32, 1.02) 1.30 (0.91, 1.86)
  1000–4999 3.48 (1.99, 6.10) 0.10 (0.05, 0.24) 0.38 (0.21, 0.70) 0.84 (0.61, 1.14)
  ≥ 5000 14.75 (7.34, 29.66) 0.46 (0.17, 1.28) 0.19 (0.07, 0.50) 2.39 (1.60, 3.57)
  p-value <0.0001 <0.0001 0.0004 <0.0001
  p-trend <0.0001 <0.0001 <0.0001 0.034

Abbreviation: aOR= adjusted odds ratio; CI = confidence interval

Note: p-values are for heterogeneity

*

In addition to the adjustment for age, sex, proximity to water and population density of children 0–15 years, the associations are mutually adjusted for all variables included in the multivariate model. In addition, the multivariate models were adjusted for keeping animals inside the house or nearby (chicken, pigs, goat, cows, birds, dogs).

This column shows the observed associations based on data from all the three study countries combined, adjusted for each country

The months of April to June and September to December were classified as wet season months, while the months of January to March and July to August were classified as dry season months.

§

Income was categorized based on the international poverty line of $1.90 per a day to calculate the average 30-day monthly income. Total household income or father’s income were not analyzed because the results for these were considered unreliable.