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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Eur J Med Chem. 2019 Sep 4;183:111673. doi: 10.1016/j.ejmech.2019.111673

Figure 1.

Figure 1.

Lead optimization guided by crystal structure of compound 1 bound to ChTS. A. Compound 1 bound in ChTS active site, hydrogen bond between γ-carboxylate with S290 denoted by black dotted line. B. Structure of compound 1 and scaffolds used for lead optimization.