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General scheme for the synthesis of compounds 2–9 and 11–25.
aReagents, conditions: (a) Et3N, DCM, r.t., o.n.; (b) MeI, NaH, DMF, r.t., o.n.; (c) Allyl alcohol, NaHCO3, Pd(OAc)2, Bu4NCl, 70 °C, o.n.; (d) 5,5-dibromo meldrum’s acid, HCl, THF, r.t., 18h; (e) 2,6-diaminopyrimidin-4-ol, NaOAc, MeOH/H2O, 45 °C, 2h; (f) 2N NaOH, MeOH/H2O, 60 °C, 1h; (g) NaN3, DMSO, 100 °C, o.n.
